J Korean Ophthalmol Soc.  1998 Jun;39(6):1095-1103.

The Effect of Limbal Transplantation & Cyclosporine A for Chemically Damaged Rabbit Cornea

• Jeong JS
• Oh TH
• Moon NJ

Abstract

The authors have evaluated the effect of topically applied 1% cyclosporine A for four weeks after limbal allograft transplantation for ocular surface stability in severely ocular surface damaged rabbits. A total eleven severely damaged rabbits were subdivided into three groups of four limbal autograft (AUTO), three limbal allograft (ALLO), four limbal allograft with topical application of 1% cyclosporine A five times daily for four weeks (ALLO-C). We examined ocular surface smoothness, clarity, corneal vascularization before surgery and three months after surgery, and classified three grade (success, partial success, failure) according to result. In AUTO, three eyes were success, one eye was failure. In ALLO, one eye showed inferior graft detachment and one eye was success, two eyes were failire. In ALLO-C, no graft detachment detected and one eye was success, two eyes were partial success, one eye was failure. We knew that. ALLO-C show more effective ocular surface stability than ALLO. These result suggest ALLO-C can be used as alternative treatment of AUTO in ocular surface reconstruction. But, rnore study for duration and concentration of cyclosporin A will be need.

Keyword

Cyclosporin A; Limbal allograft; Lirnbal autograft; Ocular surface reconstruction

MeSH Terms

Allografts
Autografts
Cornea*
Cyclosporine*
Rabbits
Transplants
Cyclosporine