The Effect of Cyanoacrylate Glue on Wound Healing of The Cornea Following Rabbit Radial Keratotomy

Han, Kyu Heon; Kim, Jung Woo; Choi, Tae Hoon

Abstract

The authors performed conventional radial keratotomy(RK) in one eye(Keratotomy group) and RK with cyanoacrylate glue in the other eye(Glue group) for 5 rabbits and compared the diopteric changes between before and four weeks after operation. The refractory power(mean+/-SD) of the cornea meassured with keratometer before the RK was 51.53 +/- 0.77 diopter(D) in Keratotomy group and 51.98 +/- 0.84D in Glue group. It was reduced four week after RK by 4.73 +/- 1.94D and 7.15 +/- 1.46D. respectively. The change of refractive power between two groups showed a statistically significant difference(p<0.05). There was no statistically significant difference of astigmatism between two groups(p>0.05). Histologic examination was performed with 4 eyes of 2 rabbits 4 week after RK. It was found in both groups that same pattern of epithelial plug and irregulaly oriented collagen fibers in stroma. However, the epithelial plug was more prominent in RK group than in Glue group. In conclusion, it was found that that RK with cyanoacrylate glue was more effective in reduction of keratometic diopter than keratotomy alone and the reason seemed to be a decreased epithelial plug in a keratotomy wound.