J Korean Ophthalmol Soc.  1995 Nov;36(11):1938-1946.

Experimental Subretinal Neovascularization Induced with Argon Laser in Pigmented Rabbits

• Kang SW
• Lee SW

Abstract

The subretinal neovascularization(SRN) is the leading cause of blindness in various retinal degenerative disease. Yet the mechanism of subretinal new vessel formation is not fully known. We induced SRN using laser photocoagulation in the rabbit and investigated the efficacy of various combinations of laser parameters. In the present study, eighteen eyes of nine pigmented rabbits underwent argon laser photocoagulation, with different settings of power, spot size, and exposure time, Fluorescein angiography was performed 1, 3 and 8 wks after photocoagulation to evaluate the development of SRN, and the light microscopic and electron microscopic examination was done to verify it at the 3rd and 8th week. The mean incidence of SRN was 48.6%, SRN developed with the highest incidence(67%) when using the setting of 1000mW, 0.2 sec, 250 micrometer (P<0.01). Intraoperative retinal hemorrhage increased the incidence of SRN up to 76.4%(P<0.05). Our result provides the most efficient laser parameters to induce experimental SRN in the pigmented rabbits.

Keyword

Experimental; Laser; Rabbit; Subretinal Neovascularization

MeSH Terms

Argon*
Blindness
Fluorescein Angiography
Incidence
Light Coagulation
Rabbits*
Retinal Hemorrhage
Retinaldehyde
Argon
Retinaldehyde