J Korean Ophthalmol Soc.
1992 Apr;33(4):342-348.
Clearance of Intravitreal Gentamicin
- Affiliations
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- 1Department of Ophthalmology, School of Medicine Kyungpook National University, Tageu, Korea.
- 2Department of Clinical Pathology, School of Medicine Kyungpook National University, Tageu, Korea.
Abstract
- Bacterial endophthalmitis is a very difficult ophthalmic disease to treat because of the consistently poor results with conventional therapy. lntravitreal injection of antibiotics is increasingly gaining the acceptance as a method of producing high vitreal concentrations that may be useful in the treatment of bacterial endophthalmitis. The author performed this experiment to determine the clerance rare of intravitreal gentamicin in the rabbit eyes. We observed the clearance of gentamicin in phakic and aphakic rabbit eyes into which 20 micro gram/0.1 ml of gentamicin was injected. In phakic eyes, about 52% of gentamicin was cleared at 24 hours after injection. In aphakic eyes with intact posterior capsule, 64% of gentamicin was cleared at 24 hours after injection. In aphakic eyes with incised posterior capsule, the clearance rate at 24 hours after injection was about 70%. Intravitreal gentamicin was cleared more rapidly from the aphakic eyes than from that of phakic eyes.
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