J Korean Ophthalmol Soc.  2008 Jun;49(6):1033-1040. 10.3341/jkos.2008.49.6.1033.

Two Cases of Topiramate-induced Acute Myopia

• Kim SW
• Seo SG
• Her J
• Ahn KS
• Choi BJ

• KMID: 2110889
• DOI: http://doi.org/10.3341/jkos.2008.49.6.1033

Abstract

PURPOSE: We describe 2 cases of bilateral acute myopia associated with topiramate, a drug that has recently been prescribed for epilepsy or weight reduction.
CASE SUMMARY
A 24-year-old woman and a 25-year-old woman, both previously devoid of ocular problems, visited our hospital with blurry vision after taking topiramate for weight reduction. A thorough medical history review and ocular examinations, including a slit lamp examination, were performed.
CONCLUSIONS
Slit-lamp examinations revealed forward displacement of the lens-iris diaphragm, which resulted in myopia and anterior chamber shallowing. Discontinuation of topiramate and the administration of cycloplegic agents successfully resolved the symptoms.

Keyword

Acute myopia; Cycloplegic agent; Topiramate

MeSH Terms

Adult
Anterior Chamber
Diaphragm
Displacement (Psychology)
Epilepsy
Female
Fructose
Humans
Myopia
Vision, Ocular
Weight Loss
Young Adult
Fructose

Figure

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  Figure 1. (Case 1) Note shallow anterior chamber (3 corneal thickness deep centrally) at initial presentation. (A) and (B) the right eye; (C) and (D) the left eye.

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  Figure 2. (Case 1) Her anterior chamber deepened (6 corneal thickness deep centrally) with cycloplegics after cessation of topiramate. (A) and (B) the right eye; (C) and (D) the left eye.

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  Figure 3. (Case 2) Her fundus photograph suggests no specific finding.

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  Figure 4. (Case 2) Her OPD scan of the right eye. Note refractive error (-7.50/-0.50×46).

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  Figure 5. (Case 2) Her OPD scan of the left eye. Note refractive error (-7.50/-0.75×89).

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  Figure 6. (Case 2) Her refractive error is (-0.25/-0.25×119) with cycloplegics after cessation of topiramate. Right eye.

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  Figure 7. (Case 2) Her refractive error is (-0.50/-0.25×92) with cycloplegics after cessation of topiramate. Left eye.

Reference

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