Korean J Anesthesiol.  1996 Nov;31(5):634-639. 10.4097/kjae.1996.31.5.634.

TEG Assessment of The Effect of Tranexamic Acid on Fibrinolysis during Open Heart Surgery

• Shin CM
• Kim JL
• Choe YG
• Kim YJ
• Park JW
• Park JY

• KMID: 2091028
• DOI: http://doi.org/10.4097/kjae.1996.31.5.634

Abstract

BACKGROUND: Activated fibrinolysis during cardiopulmonary bypass(CPB) is one of the causes of post CPB coagulopathy. Antifibirinolytics such as tranexamic acid have been administered prophylactically before CPB to decrease postCPB bleeding. However, their routinely application has been challenged as regarding it's thrombotic complication. This study was performed to evaluate the effect of tranexamic acid administered before CPB by thromboelastography.
METHODS
50 open heart surgical patients were randomly selected and devided into two groups, control(N=25) and tranexamic acid group(N=25). In tranexamic acid group. 125mg of tranexamic acid were singly infused before vena caval and aortic cannulation. All of parameters of thromboelastography (TEG) and fibrin degradation products measured before and after CPB were compared between two groups.
RESULTS
There were no significant differences in fibrinolytic indexes of TEGs between control group and tranexamic group afte CPB. And there were also no changes in fibrinolysis index between before and after CPB in both groups. The concentration of FDP did not changed after CPB in both groups.
CONCLUSIONS
It may be considered that prophylactic administration of tranexamic acid before CPB to reduce post-CPB bleeding would not be recommended routinely.

Keyword

Blood fibrinolysis; Equipment thromboelastograph; Heart cardiopulmonary bypass

MeSH Terms

Catheterization
Fibrin Fibrinogen Degradation Products
Fibrinolysis*
Heart*
Hemorrhage
Humans
Thoracic Surgery*
Thrombelastography
Tranexamic Acid*
Fibrin Fibrinogen Degradation Products
Tranexamic Acid