Korean J Dermatol.  2007 Jul;45(7):687-691.

A Case of CD30 Positive ALK-Negative Systemic Anaplastic Large Cell Lymphoma Involving Bone Marrow

• Lee YH
• Kim SH
• Suh MK
• Jang TJ

Abstract

CD 30 positive anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin's lymphoma, a tumor that is composed of mostly mast cells expressing CD30 antigens. According to the 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification, it can be classified as systemic ALCL and primary cutaneous CD30 positive T-cell lymphoproliferative disorder. Systemic ALCL can be subclassified into ALK positive and negative. There have been many cases of primary cutaneous CD30 positive T-cell lymphoproliferative disorder, but reports of systemic ALCL have been rare. We report a case of CD30 positive/ALK negative systemic anaplastic large cell lymphoma involving bone marrow in a 51 year-old-male who showed two pruritic, 1.5x1.0x0.8 cm and 1.0x0.5x0.4 cm sized, erosive, erythematous nodules on the right thigh and calf.

Keyword

Anaplastic large cell lymphoma; Bone marrow involvement

MeSH Terms

Antigens, CD30
Bone Marrow*
Classification
Lymphoma, Large-Cell, Anaplastic*
Lymphoma, Non-Hodgkin
Lymphoproliferative Disorders
Mast Cells
T-Lymphocytes
Thigh
World Health
World Health Organization
Antigens, CD30