Korean J Hepatol.
2000 Dec;6(4):456-467.
Treatment Outcome and Prognostic Factors in Patients with Advanced Hepatocellular Carcinoma (TNM Stage IVa) according to Anticancer drugs of Transhepatic Arterial Chemoinfusion
- Affiliations
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- 1Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea.
- 2Department of Diagnostic Radiology, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND/AIMS: The study proposed to evaluate the efficacy of anticancer drugs of intraarterial chemoinfusion and investigate prognostic factors influencing survival.
METHODS
A total of 127 patients diagnosed as having advanced hepatocellular carcinoma(HCC) of same stage (TNM stage IVa) from 1996 to 1998 were examined. Two intraarterial infusion chemotherapeutic regimens were employed: Adriamycin(Group I) and Cisplatin(Group II).
RESULTS
Overall survival was significantly diffrent(10.0 vs 5.7months) and favored Group I. By the univariate analysis, significant prognostic factors included: age, portal vein thrombosis(PVT), size(>5cm) and type of tumor, response rate (size & -fetoprotein) at 3 months after therapy, level of albumin, alkaline phosphatase, and total bilirubin. After repeated therapy, Group I showed better survival (14.0 vs 7.9 months), but there was no statistical difference in survival rate between two groups in the case of large size, PVT, and diffuse type.
CONCLUSION
Group I showed better survival than Group II in advanced HCC of TNM stage IVa. But, considering prognostic factors, there was no significant difference in survival rate between two groups except small size or nodular type of HCC. TNM classification of stage IVa should be reconsidered to include prognostic factors influencing survival rate such as PVT, size and type of HCC.
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