J Korean Med Sci.  2014 Nov;29(11):1544-1549. 10.3346/jkms.2014.29.11.1544.

Prevalence of Congenital Heart Defects Associated with Down Syndrome in Korea

• Kim MA
• Lee YS
• Yee NH
• Choi JS
• Choi JY
• Seo K

• KMID: 2069937
• DOI: http://doi.org/10.3346/jkms.2014.29.11.1544

Abstract

Congenital heart defect (CHD) is common in infants with Down syndrome (DS), which is the principle cause of mortality. However, there is no data available for the frequency and types of CHD in infants with DS in Korea. We investigated the frequency of CHD in infants with DS in Korea. After the survey on birth defects was conducted throughout the country, the prevalence of CHD in DS in 2005-2006 was calculated. This study was conducted based on the medical insurance claims database of the National Health Insurance Corporation. The number of total births in Korea was 888,263 in 2005-2006; of them, 25,975 cases of birth defects were identified. The prevalence of DS was 4.4 per 10,000 total births, accounting for 1.5% of all birth defects. Of the 394 infants with DS, 224 (56.9%) had a CHD. Atrial septal defect was the most common defect accounting for 30.5% of DS followed by ventricular septal defect (19.3%), patent duct arteriosus (17.5%), and atrioventricular septal defect (9.4%). Our study will be helpful to demonstrate the current status of DS and to identify the distribution of CHD in infants with DS in Korea.

Keyword

Down Syndrome; Heart Defects, Congenital; Prevalence, Korea

MeSH Terms

Adult
Asian Continental Ancestry Group
Birth Weight
Chromosome Aberrations
Databases, Factual
Down Syndrome/*complications
Ductus Arteriosus, Patent/epidemiology
Female
Gestational Age
Heart Defects, Congenital/*epidemiology/etiology
Heart Septal Defects/epidemiology
Heart Septal Defects, Atrial/epidemiology
Heart Septal Defects, Ventricular/epidemiology
Humans
Male
Prevalence
Republic of Korea/epidemiology