J Korean Soc Radiol.  2015 Oct;73(4):264-268. 10.3348/jksr.2015.73.4.264.

Primary Breast Lymphoma in an Immunocompromised Male Patient: A Case Report

Affiliations
  • 1Department of Radiology, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea. jsp@hanyang.ac.kr
  • 2Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
  • 3Department of Nuclear Medicine, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.
  • 4Department of Pathology, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.

Abstract

Primary breast lymphoma in a male patient is extremely rare. We report a case of primary breast lymphoma in an immunocompromised male patient, after renal transplantation. The sonographic and histological features are described in depth.


MeSH Terms

Breast*
Humans
Kidney Transplantation
Lymphoma*
Male*
Ultrasonography

Figure

  • Fig. 1 High frequency US images show left breast mass. A. Transverse US scan shows an oval, circumscribed mass with complex internal echo pattern and without posterior acoustic phenomena. B. Transverse Doppler US scan shows internal hypervascularity. C. H&E stained lymph node section demonstrates diffuse proliferation of large lymphoid cells with effaced architecture (H&E stain, × 400). D. CD20 stain demonstrates positivity in large lymphocytes (× 400). E. Transverse MDCT image after contrast administration shows homogeneously enhancing mass (arrow) in the left breast. F. Transverse PET/CT scans show hypermetabolic mass (arrow) in the left breast. Absence of uptake in abdominal, mediastinal, or cervical regions indicates the absence of systemic disease or distant metastases. CT = computed tomography, H&E = hematoxylin and eosin, MDCT = multi-detector computed tomography, PET = positron emission tomography, US = ultrasound


Reference

1. Tran H, Nourse J, Hall S, Green M, Griffiths L, Gandhi MK. Immunodeficiency-associated lymphomas. Blood Rev. 2008; 22:261–281.
2. Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP. Lymphomas of the breast: primary and secondary involvement. Cancer. 2002; 94:6–13.
3. Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer. 1972; 29:1705–1712.
4. Liberman L, Giess CS, Dershaw DD, Louie DC, Deutch BM. Non-Hodgkin lymphoma of the breast: imaging characteristics and correlation with histopathologic findings. Radiology. 1994; 192:157–160.
5. Lyou CY, Yang SK, Choe DH, Lee BH, Kim KH. Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging. 2007; 31:234–238.
6. Yang WT, Lane DL, Le-Petross HT, Abruzzo LV, Macapinlac HA. Breast lymphoma: imaging findings of 32 tumors in 27 patients. Radiology. 2007; 245:692–702.
7. Hwang JY, Cha ES, Lee JE, Sung SH. Isolated post-transplantation lymphoproliferative disease involving the breast and axilla as peripheral T-cell lymphoma. Korean J Radiol. 2013; 14:718–722.
8. Asch WS, Bia MJ. Oncologic issues and kidney transplantation: a review of frequency, mortality, and screening. Adv Chronic Kidney Dis. 2014; 21:106–113.
9. Kasiske BL, Snyder JJ, Gilbertson DT, Wang C. Cancer after kidney transplantation in the United States. Am J Transplant. 2004; 4:905–913.
10. Cronin CG, Swords R, Truong MT, Viswanathan C, Rohren E, Giles FJ, et al. Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol. 2010; 194:W91–W103.
Full Text Links
  • JKSR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr