J Korean Neurol Assoc.
1995 Dec;13(4):1037-1041.
Familial Tuberous Sclerosis
- Affiliations
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- 1Department of Neurology, Taegu Catholic University Hospital, Korea.
Abstract
- Tuberous sclerosis (TS) is a complex genetic disorder characterized by the formation of multiple hamartomas. It was first described by von Recklinghausen in 1862. In 1880, Boumeville coined the term sclerose tubererse. In 1908, Vogt emphasized the classic triad of seizures, mental retardation, and adenoma sebaceum. TS is inherited as an autosomal dominant trait with a high incidence of sporadic cases. TS might be a relatively common disease, but familial cases were not reported commonly in neurological field. We reported a familial TS in brothers with protean clinical expressivity.
