Korean J Urol.  2007 Sep;48(9):903-909. 10.4111/kju.2007.48.9.903.

Efficacy of Renal Artery Embolization using a Mixture of Histoacryl(R) and Lipiodol in a Rabbit Model

• Lee KH
• Cho SY
• Park DJ
• Yoon BI
• Kim SW
• Gwon DI
• Paik MH
• Kim HW

• KMID: 2061289
• DOI: http://doi.org/10.4111/kju.2007.48.9.903

Abstract

PURPOSE
We wanted to evaluate the efficacy and computed tomography(CT) findings of renal artery embolization with using a mixture of Histoacryl(R) and lipiodol in rabbit depending on the mixture proportions and the temporal course.
MATERIALS AND METHODS
Eighteen rabbits were equally divided into two groups: group A received a 1:3 mixture and group B received a 1:5 mixture of Histoacryl(R) and lipiodol. We subdivided each group as follows: the 1-day group, the 10-day group and the 20-day group according to the elapsed days after embolization, respectively. As a result, the experimental groups were composed of six subgroups. Afterright renal artery embolizations, plain abdominal radiographs were obtained from all the rabbits. On the first day, the 10th day and the 20th day after embolization, abdominal CT was performed in each subgroup.
RESULTS
On the post-embolization radiographs, the embolic casts were formed only at the main or segmental renal arteries in 7 cases of group A. On the other hand, the embolic casts were formed at the entire arterial trees in two cases of group A and all the cases of group B. On the pre- contrast-enhanced CT scans, there were radiopaque densities of embolic casts, residual lipiodol flecks and calcifications in the embolized kidneys. On the contrast-enhanced CT scans, global perfusion defects of the kidneys were noted in 17 rabbits. The cortical rim signs were noted in all rabbits of the 10-day and 20-day groups, except for one rabbit.
CONCLUSIONS
The mixture of Histoacryl(R) and lipiodol is effective for renal artery embolization. The CT findings of the embolized kidneys are characteristic depending on the mixture proportions of the embolic agents and the temporal courses.

Keyword

Renal artery; Therapeutic embolization; Tomography

MeSH Terms

Embolization, Therapeutic
Ethiodized Oil*
Hand
Kidney
Perfusion
Rabbits
Renal Artery*
Tomography, X-Ray Computed
Ethiodized Oil

Figure

• 

  Fig. 1 Immediate post-embolization angiograms show a radio-opaque embolic cast of Histoacryl® and lipiodol in the main renal artery (arrow) in group A (A) and in the entire arterial trees of the kidney in group B (B).

• 

  Fig. 2 After embolization, pre-contrast CT scans show linear and nodular radiopaque embolic casts and lipiodol flecks (arrows) in the main renal artery and kidney of group A (A), and circumferential lipiodol flecks (arrow) were seen in the kidney, mainly at the cortex of group B (B).

• 

  Fig. 3 After embolization, post-contrast CT scans show the complete absence of renal enhancement in groups A and B (A) with only one exception in group B-3 (B).

• 

  Fig. 4 After embolization, post-contrast CT scans show no cortical rim sign in group A-1 (A) and a cortical rim sign (arrow) is seen in group A-3 (B).

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