Gut Liver.  2013 Jan;7(1):51-57.

The Effect of the Menstrual Cycle on Inflammatory Bowel Disease: A Prospective Study

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. geniushee@yuhs.ac
  • 2Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Nursing, Yonsei University College of Nursing, Seoul, Korea.
  • 4Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  • 5Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS
The symptoms of inflammatory bowel disease (IBD) fluctuate considerably over time. However, it has not been determined whether these symptoms are affected by the menstrual cycle in female IBD patients. This study analyzed the effects of the menstrual cycle on IBD symptom variation.
METHODS
This was a prospective study of 91 study subjects (47 IBD patients and 44 healthy controls) who reported daily symptoms and signs throughout their menstrual cycles.
RESULTS
IBD patients had significantly more frequent gastrointestinal symptoms, such as nausea (30% vs 7%, p=0.006), flatulence (53% vs 22%, p=0.003), and abdominal pain as compared to controls (68% vs 38%, p=0.006). The IBD patients also experienced more frequent systemic premenstrual symptoms than the controls (79% vs 50%, p=0.003). More severe abdominal pain (p=0.002) and lower mean general condition scores (p=0.001) were noted during the menstrual phase as compared to the pre- or post-menstrual phase in both groups. IBD patients experienced more frequent premenstrual gastrointestinal symptoms than controls, but their IBD symptoms did not change significantly during the menstrual cycle.
CONCLUSIONS
Knowledge of the cyclic alterations in gastrointestinal and systemic symptoms may be helpful in determining the true exacerbation of disease in female IBD patients.

Keyword

Inflammatory bowel diseases; Menstrual cycle; Women
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