Ann Clin Microbiol.  2015 Sep;18(3):94-97. 10.5145/ACM.2015.18.3.94.

Successful Treatment of Fungemia Caused by Cyberlindnera fabianii with Anidulafungin: A Case Report

• Lee JI
• Yu S
• Park JS
• Joo EJ
• Shin JH
• Kwon MJ

• KMID: 2052103
• DOI: http://doi.org/10.5145/ACM.2015.18.3.94

Abstract

Cyberlindnera fabianii (previously known as Hansenula fabianii, Pichia fabianii, and Lindnera fabianii) is a yeast species that forms a biofilm, allowing it to resist azole drugs. In this study, we report a case of fungemia with C. fabianii that was successfully treated with anidulafungin. In this case, the organism was initially misidentified as Candida utilis (with a high probability of 93%, suggesting good identification) using the VITEK 2 yeast identification card (YST ID; bio-Merieux, USA). The species responsible for the patient's fungemia was correctly identified after sequencing the internally transcribed spacer region and the D1/D2 domain of the large subunit (26S) rDNA gene. The CLSI M27-A3 broth microdilution method was used to determine the in vitro antifungal activity of anidulafungin and fluconazole against C. fabianii. The MICs of anidulafungin and fluconazole were found to be 0.03 microg/mL and 2 microg/mL, respectively. The patient recovered after 14 days of anidulafungin treatment.

Keyword

Anidulafungin; Cyberlindnera fabianii

MeSH Terms

Biofilms
Candida
Danazol
DNA, Ribosomal
Fluconazole
Fungemia*
Humans
Pichia
Yeasts
DNA, Ribosomal
Danazol
Fluconazole

Figure

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  Fig. 1. Colony morphology on sub-inoculation and microscopic morphology. (A) Small white colonies identified after incubation on a blood agar plate at 35oC in the presence of 5% CO2. (B) Microscopic analysis revealed variably sized Gram-positive yeast-like structures in the colonies (Gram stain,×1,000).

Reference

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