Korean J Pediatr Hematol Oncol.
2000 Oct;7(2):305-309.
A Case of Cerebral Infarction in a Child with Acute Lymphoblastic Leukemia Developed during Chemotherapy with E coli Asparaginase
- Affiliations
-
- 1Department of Pediatrics, School of Medicine, Hallym University, Seoul, Korea.
- 2Department of Radiology, School of Medicine, Hallym University, Seoul, Korea.
Abstract
- E. coli L-asparaginase treatment during induction therapy in acute lymphoblastic leukemia is known to be rarely complicated by thromboembolic events. It causes deficiencies of antithrombin III, plasminogen, fibrinogen, factor IX, XI, protein C and protein S. We recently experienced a case of infarction during induction therapy in a 9-year-old child diagnosed with ALL. After the four dose of L-asparaginase, she had a generalized tonic- clonic seizure and MRI of the head showed both occipital infarction. She had gross recovery of the neurological impairment in 4 days. We report this case with brief review of literature.
MeSH Terms
-
Antithrombin III
Asparaginase*
Cerebral Infarction*
Child*
Drug Therapy*
Escherichia coli*
Factor IX
Fibrinogen
Head
Humans
Infarction
Magnetic Resonance Imaging
Plasminogen
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Protein C
Protein S
Seizures
Antithrombin III
Asparaginase
Factor IX
Fibrinogen
Plasminogen
Protein C
Protein S
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Four Cases of Acute Parotitis in Acute Lymphoblastic Leukemia Patients Developed during Induction Chemotherapy Including L-Asparaginase
- Effectiveness of premedication and rapid desensitization in hypersensitivity to L-asparaginase
- A Clinical Study of the Side Effects of L-Asparaginase
- Acute Necrotizing Pancreatitis during L-asparaginase Treatment in a Patient with Acute Lymphoblastic Leukemia
- Hemostatic Changes and Effect of Antithrombin III Replacement Therapy in Children with Acute Lymphoblastic Leukemia
