Korean J Anesthesiol.  1998 Mar;34(3):543-547. 10.4097/kjae.1998.34.3.543.

The Infusion Rate of Cisatracurium and Its Spontaneous Recovery for Cesarean Section under Enflurane Anesthesia

• Lee SK
• Kim JL
• Choi MY
• Kwak HJ
• Shin YS

• KMID: 2032417
• DOI: http://doi.org/10.4097/kjae.1998.34.3.543

Abstract

BACKGROUND
Cisatracurium, one of 10 isomers of atracurium, undergoes pH and temperature-dependent Hofmann elimination in plasma and tissues. Physiologic changes may affect the pharmacodynamics of neuromuscular bldegrees Cking agent during pregnancy. So, we compared the difference in the infusion rate and its spontaneous recovery of cisatracurium between full-term pregnant and nonpregnant women.
METHODS
Muscle relaxation of full-term pregnant(group I, n=10) and nonpregnant(group II, n=10) women was maintained by continuous infusion of cisatracurium to keep 1st twitch response of train-of-four(TOF) at 5~10% of control. After discontinuation of infusion, recovery index was measured without reversals using the accelerograph.
RESULTS
The infusion rate of cisatracurium in group I(1.25+/-0.16 mcg/kg/min) was not significantly different from that in group II(1.31+/-0.22) and recovery indices were not different between two groups(10.7+/-2.0 vs. 11.6+/-1.9 min).
CONCLUSION
The infusion rate of cisatracurium in parturients to maintain surgical relaxation is not different from that in non-parturients. For Cesarean section, the usual infusion rate of cisatracurium is recommeneded to achieve the adequate surgical relaxation.

Keyword

Neuromuscular relaxants: cisatracurium; Surgery: Cesarean section

MeSH Terms

Anesthesia*
Atracurium
Cesarean Section*
Enflurane*
Female
Humans
Hydrogen-Ion Concentration
Muscle Relaxation
Plasma
Pregnancy
Relaxation
Atracurium
Enflurane