Korean Circ J.  2001 Oct;31(10):1071-1074. 10.4070/kcj.2001.31.10.1071.

A Case of Vasospastic Angina Pectoris Occurring Following Administration of Oral Imigran(R) for Migraine

• Choi KH
• Kim TY
• Choi JH
• Ok JW
• Park JC
• Oh J
• Cho YK
• Hwang KH
• Lim SW
• Cha DH

• KMID: 2029595
• DOI: http://doi.org/10.4070/kcj.2001.31.10.1071

Abstract

Imigran(R) (sumatriptan), a 5-hydroxytryptamine (HT) derivative, is highly effective in aborting attacks of migraine and cluster headache. The drug is generally well tolerated. However tolerated, although up to 8% of patients consistently have demonstrate chest symptoms, including chest pressure, tightness, and pain, often mimicking angina pectoris. It has been suggested that these chest symptoms are caused by coronary vasoconstriction, and that this effect may be mediated by endothelial dysfunction. This can be reversed by the administration of glyceryl trinitrate. We report a case of vasospastic angina pectoris occurring after the administration of oral sumatriptan in a patient with migraine.

Keyword

Sumatriptan; Migraine; Angina pectoris; variant

MeSH Terms

Angina Pectoris*
Cluster Headache
Humans
Migraine Disorders*
Nitroglycerin
Serotonin
Sumatriptan
Thorax
Vasoconstriction
Nitroglycerin
Serotonin
Sumatriptan