Serum Concentration of CA-125 during the First Trimester of Normal and Abnormal Pregnancies

Ro, Duck Yeong; Kim, Do Kang; Kim, Soo Pyung; Moon, Hee Bong; Kang, Gyu Sub; Hwang, Jee Young; Shin, Bong Young; Jang, Byeung Woo

Abstract

A prospective study was initiated to compare maternal serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. Serum specimens were obtained from 87 women with a normal intrauterine pregnancy and 47 women with abnormal pregnancies which were ended in spontaneo abortion or pathologically confirmed to be missed abortion. In normal pregnancies, the mean serum CA-125 concentrations were increased significantly from amenorhea 6 weeks (139.838.7 IU/ml), and were higher statistically than the values tested in the same weeks of abnormal pregnancies. In abnormal pregnancies serum CA-125 concentations were relatively lower than those of normal pregnancies. But these differences were not statistically significant except the values tested in amenorhea 6weeks. So serum levels of CA-125 may not be proved useful in monitoring of early pregnancies outcome.