J Korean Radiol Soc.  2007 May;56(5):491-495. 10.3348/jkrs.2007.56.5.491.

MR Imaging of Endometrial Cancer that Occurs After Radiation Therapy for Cervix Cancer

Affiliations
  • 1Department of Diagnostic Radiology, Inha University Hospital, Korea. yjeong@chonnam.ac.kr
  • 2Department of Diagnostic Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Korea.
  • 3Department of Diagnostic Radiology, Kwangju Christian Hospital, Korea.
  • 4Department of Diagnostic Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Abstract

PURPOSE: We wanted to describe the MR imaging findings of endometrial cancer in patients with a history of prior radiation therapy for cervical cancer (ECRT) and we compare them to the MR imaging findings of patients with spontaneously occurring endometrial cancer (SEC).
MATERIALS AND METHODS
Twenty-two patients with endometrial cancer that was diagnosed by operation or endometrial biopsy were included in the study. The patients were divided into two groups according to the presence of past RT for cervical cancer: ECRT (n = 4) and SEC (n = 18). The MR images were retrospectively analyzed by consensus of two experienced radiologists. The MR imaging findings were analyzed by the size, shape and signal intensity of the mass, distension of the uterine cavity, the presence of cervical stenosis and the nature of the fluid collection.
RESULTS
For the mass shape, all the ECRT lesions were polypoid masses. However, the SEC patients had 5 polypoid masses and 13 wall thickenings. The maximal diameter, signal intensity and enhancement pattern of the masses were not different between the ECRT and SEC patients. The width of the endometrial cavity varied between 3.9 cm in the ECRT patients and 0.4 cm in the SEC patients (p =0.002). All the ECRT patients had cervical stenosis. However, none of the SEC patients had cervical stenosis.
CONCLUSION
MR imaging of ECRT patients demonstrated prominent distension of their uterine cavity and cervical stenosis, which may be the result of radiation fibrosis in the uterus.

Keyword

Uterine neoplasms, MR; Uterus, endometrium; Radiations; Injurious effects; Complications of therapeutic radiology
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