Korean J Dermatol.  2002 May;40(5):522-526.

A Case of Drug Eruption Caused by Rifampin and Isoniazid

• Tak WJ
• Chang DS
• Seo SJ
• Hong CK

Abstract

Drug eruption is a cutaneous reaction caused by various drugs, which include antibiotics, antipyretics, anti-inflammatory analgesics, antidepressants, antituberculosis drugs, etc. Drug eruptions caused by antituberculosis drugs are relatively uncommon and there have been no previous reports in Korea which caused simultaneously by isoniazid and rifampin. A 57-year-old female patient, who was treated with antituberculosis drugs, was seen with generalized erythematous maculopapular eruption. We performed patch test and prick test with the antituberculosis drugs and could confirm a drug eruption caused by isoniazid and rifampin. And we performed desensitization to isoniazid for an optimal antituberculosis regimen and completed the treatment with isoniazid, successfully.

Keyword

Drug eruption; Isoniazid; Rifampin

MeSH Terms

Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Antidepressive Agents
Antipyretics
Drug Eruptions*
Female
Humans
Isoniazid*
Korea
Middle Aged
Patch Tests
Rifampin*
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Antidepressive Agents
Antipyretics
Isoniazid
Rifampin