Korean J Cytopathol.  2000 Jun;11(1):47-52.

Fine Needle Aspiration Cytology of Diffuse Sclerosing Variant of Papillary Carcinoma of the Thyroid: A Case Report

• Kim JM
• Min SK
• Chu YC
• Kim MR
• Kim KR

Abstract

Diffuse sclerosing papillary carcinoma(DSPC), a variant of papillary carcinoma of the thyroid, is characterized by diffuse involvement of one or both thyroid lobes, and histologic features such as prominent sclerosis, intense lymphocytic infiltrate, num erous psammoma bodies, and squamous metaplasia together with the charac teristic cytoarchitectural pattern of classical papillary carcinoma. We experienced a case of fine needle aspiration cytologic(FNAC) findings of DSPC, which was con firmed by histologic examination of the thyroidectomy specimens. The patient was 26 years old female who presented with diffuse firm enlargement of the thyroid gland with enlargement of many cervical lymph nodes. FNAC smears showed numerous psammoma bodies, many lymphocytes, metaplastic squamous cells, absence of stringy colloid, and epithelial cells showing classical features of papillary carcinoma, such as nuclear grooves, intranuclear inclusions, and ground glass chromatin pattern.

Keyword

Diffuse sclerosing variant; Papillary carcinoma; Fine needle aspiration cytology; Thyroid gland

MeSH Terms

Adult
Biopsy, Fine-Needle*
Carcinoma, Papillary*
Chromatin
Colloids
Epithelial Cells
Female
Glass
Humans
Intranuclear Inclusion Bodies
Lymph Nodes
Lymphocytes
Metaplasia
Sclerosis
Thyroid Gland*
Thyroidectomy
Chromatin
Colloids