J Korean Soc Radiol.  2011 Oct;65(4):399-402. 10.3348/jksr.2011.65.4.399.

Magnetic Resonance Imaging Finding of Metastatic Hepatocellular Carcinoma in Ovary: A Case Report

  • 1Department of Radiology, Chungbuk National University Hospital, Cheongju, Korea. sircircle@chungbuk.ac.kr
  • 2Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.


Hepatocellular carcinoma is the most common primary malignant tumor of liver. Metastasis of hepatocellular carcinoma occurs in various organs, but metastasis to the ovary is extremely rare. We report MRI finding of metastatic hepatocellular carcinoma of the ovary in a 37-year-old woman who was treated hepatocellular carcinoma transarterial chemoembolization and radiofrequency ablation a year ago. Pelvic MRI revealed a mass in pelvic cavity with heterogeneous signal intensity and centripetal enhancement. Surgical excision and pathologic examination confirmed metastatic hepatocellular carcinoma in the ovary.

MeSH Terms

Carcinoma, Hepatocellular
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neoplasm Metastasis


  • Fig. 1 A. Transvaginal USG image shows a huge heterogeneous echoic mass in pelvic cavity. B, C, D. MRI reveals 11 cm-sized mass in pelvic cavity. Mass shows diffuse low signal intensity on T1 weighted image (B), and heterogeneous high signal intensity on T2 weighted image (C). Contrast enhanced T1 weighted image (D) shows heterogeneous peripheral enhancement (arrow). Note the nonenhancing central portion on contrast enhanced T1 weighted image and heterogeneous high signal intensity on T2 weighted image, suggesting necrosis (arrowhead). E, F. T1 weighted dynamic contrast enhancement images of 1 minute (E) and 5 minutes (F) shows centripetal enhancement (arrow). Note the nonenhancing low signal intensity at central portion of the mass suggesting necrosis. G. Diffuse and trabecular growth pattern of tumor cells with abundant cytoplasm and pleomorphic nuclei is shown (H&E stain, × 400). H. Immunohistochemical stain for AFP reveals positive reaction in cytoplasm of tumor cells (arrow) (Immunostain for AFP, × 400). Note.-AFP = a-fetoprotein, USG = ultrasonography


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