Korean J Fertil Steril.
2001 Sep;28(3):247.
The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion
- Affiliations
-
- 1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Sungnam, Korea.
- 2Institute for Clinical Research, College of Medicine, Pocheon CHA University, Sungnam, Korea.
- 3Department of Biological Science, Ajou University, Suwon, Korea.
Abstract
OBJECTIVE
To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. MATERIAL AND METHOD: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method.
RESULTS
Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190).
CONCLUSION
Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion Associated with Hyperhomocysteinemia
- The Analysis of Interrelationship between Homocysteine and Methylenetetrahydrofolate Reductase Mutation in Patients with Recurrent Spontaneous Abortion
- Potential Inherited Causes of Recurrent Prosthetic Mitral Valve Thrombosis in a Pregnant Patient Suffering from Recurrent Miscarriage
- A study on the genetic polymorphism of methylenetetrahydrofolate reductase in egnancy - induced hypertensive patient
- Relationship between Methylenetetrahydrofolate Reductase C677T Homozygous Mutation and Cerebral Small Vessel Disease Subtypes
