J Korean Vasc Surg Soc.  1998 Nov;14(2):231-235.

Therapeutic Effects of Lipo-Prostaglandin E1 in Buerger's Disease

• Ki SG
• Kim YW

Abstract

To observe the therapeutic effects of iv Lipo-prostaglandin E1 for the patients with Buerger's disease, 16 patients presenting severe peripheral ischemic symptom were enrolled and prospectively assessed the efficacy of Lipo-PGE1 after 4 weeks of iv bolus injection of Lipo-PGE1. Pain relief, reduction of ulcer size, change of ankle brachial index and change of toe pressure measured with photoplethysmography were assessed as end points of therapeutic efficacy. After 4 weeks of treatment, 69.2% of patients revealed pain relief, 33.3% revealed reduction of ulcer size (>50%), 18.8% revealed increased ankle brachial index (>0.15), and 18.8% revealed increased toe pressure. The side effects of iv bolus Lipo-prostaglandin E therapy was minimal.

Keyword

Buerger's disease; Prostaglandin E

MeSH Terms

Alprostadil
Ankle Brachial Index
Humans
Photoplethysmography
Prospective Studies
Thromboangiitis Obliterans*
Toes
Ulcer
Alprostadil