Korean J Gastrointest Endosc.  2011 Feb;42(2):109-112.

De Novo Submucosal Colorectal Cancer in a 3 mm Sessile Polyp

Affiliations
  • 1Institute for Digestive Research, Soonchunhyang University College of Medicine, Seoul, Korea. jokim31@hanafos.com

Abstract

The majority of colorectal carcinomas (95~100%) are thought to arise from adenomas. Yet colorectal carcinomas may rarely arise de novo. The popular definition of de novo carcinoma is that the lesion should consist exclusively of a carcinoma histologically and contain no adenomatous elements. Without an adenoma-carcinoma sequence, de novo carcinomas have a much higher rate of submucosal invasion, despite their small size. Their speed of growth is thought to be rapid. Some studies have shown that de novo carcinomas might arise as a macroscopically flat or depressed lesion, rather than a protruded one. However, the typical macroscopic findings of de novo carcinomas have not been established. They might be variable macroscopically and include a protruded type. We report a case of de novo colorectal carcinoma that invaded the submucosal layer involving a minute sessile polyp only 3 mm in diameter, which was removed by endoscopic mucosal resection.

Keyword

Submucosal invasive colorectal cancer; Early colorectal carcinoma; Minute sessile polyp; De novo carcinoma
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