Korean J Anesthesiol.  1983 Jun;16(2):138-144.

Changes in In sulin and Glucose Levels During Open Heart Surgery

  • 1Department of Anesthesiology,Yonsei University College of Medicine, Seoul, Korea.


At present glucose solution is commonly used as the priming solution in cardiopulmonary bypass and an elevated blood glucose level is seen throughout and following bypass. The relationship between elevated blood glucose levels and plasma insulin response during cardiopulmonary bypass has not been clearly established. Plasma immunoreactive insulin and blood glucose levels were studied in 13 adult patients undergoing open heart surgery with cardiopulmonary bypass. The following results were obtained: 1) With body cooling, plasma insulin levels fell despite the oevelopment of hyperglycemis. On rewarming plasma insulin levels rose markedly and blood glucose levels remained high until the procedure was ended. 2) During cardiopulmonary bypass, serum sodium levels did not show any marked fluctuation, but serum potassium levels were low compared to control values.

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