Korean J Cytopathol.  1996 Dec;7(2):207-212.

Fine Needle Aspiration Cytology of Angiosarcoma of the Rib: A Case Report

• Kim HJ
• Cho MY
• Jung SH
• Lee KG

Abstract

Angiosarcoma of the bone is rare with an incidence of 0.13%. It may be solitary or multiple. Its cytologic findings by FNA have rarely been reported. We report a case of angiosarcoma of the rib in a 66 year-old man. FNA revealed single or clusters of round to oval shaped cells in a hemorrhagic and myxoid background. The large central nuclei had irregular nuclear membrane, chromatin clumping and prominent nucleoli. The cytoplasm was scanty with an eosinophilic distinct cytoplasmic border. Erythrophagocytosis by malignant cells was also found. Histopathologic examination confirmed the diagnosis of angiosarcoma revealing irregular and com- plex anastomosing vascular channels lined by malignant round tumor cells, protruding into the lumen. Immunohistochemical staining revealed diffuse strong positive reaction to factor VIII-related antigen and CD31.

Keyword

Bone; Rib; Angiosarcoma

MeSH Terms

Aged
Biopsy, Fine-Needle*
Chromatin
Cytoplasm
Diagnosis
Eosinophils
Hemangiosarcoma*
Humans
Incidence
Nuclear Envelope
Ribs*
von Willebrand Factor
Chromatin
von Willebrand Factor