Korean J Cytopathol.  1998 Jun;9(1):89-94.

Fine Needle Aspiration Cytology of Osteoclastic Giant Cell Tumor of the Pancreas

• Sung SH
• Han WS

Abstract

A case of fine needle aspiration cytology of an osteoclastic giant cell tumor of pancreas, which is an uncommon variant of ductal adenocarcinoma, is described. Aspirated tumor cells were characterized by three populations: (1) bland osteoclast like giant cells with multiple small, round nuclei with distinct nucleoli, and abundant cytoplasm, (2) individually scattered or loosely clustered medium sized mononuclear tumor cells, having fine chromatin, smooth nuclear membrane, often prominent nucleoli, and high N/C ratio, (3) bland or atypical spindle shaped cells. Osteoid like lacy material was also seen on cell block section. The immunohistochemical studies using paraffin embedded cell block section showed positivities for vimentin and lysozyme in both giant and mononuclear tumor cells. However, they were negative for cytokeratin, epithelial membrane antigen, S-100 protein, carcinoembryonic antigen, and p53.

Keyword

Osteoclastic giant cell tumor of pancreas; Fine needle aspiration cytology

MeSH Terms

Adenocarcinoma
Biopsy, Fine-Needle*
Carcinoembryonic Antigen
Chromatin
Cytoplasm
Giant Cell Tumors*
Giant Cells*
Keratins
Mucin-1
Muramidase
Nuclear Envelope
Osteoclasts*
Pancreas*
Paraffin
S100 Proteins
Vimentin
Carcinoembryonic Antigen
Chromatin
Keratins
Mucin-1
Muramidase
Paraffin
S100 Proteins
Vimentin