Renal Tumor Registry under the Age of 20 in Korea: 1997-2001

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Abstract

PURPOSE: To date, there has been no multi-institutional report on pediatric renal tumors in Korea. Our study was undertaken to obtain valuable demographic data for a better understanding of the biological behavior and optimal management for these tumors in patients under the age of 20 years.
MATERIALS AND METHODS
The testicular tumor registry form was mailed to all 87 hospitals registered in the Korean Urology Association. The five-year medical records at each hospital were retrospectively reviewed, which included age, presentation, evaluation, treatment and outcome.
RESULTS
240 patients (0.1-19.7 years; ave. 3.6) were enrolled in this registry; the incidence of renal tumors was 0.33 per 100,000 population under the age of 20 years. Most patients were diagnosed with an abdominal mass before the age of 4 years. The pathological diagnoses were malignant and benign tumors in 90.4 and 9.6%, respectively. A Wilms' tumor was the most common (77.9%) malignant tumor, with a multilocular cystic nephroma (4.2%) in the most common benign tumor. 20.2% of patients were accompanied by other diseases, such as hypertension, hemihypertrophy, cryptorchidism and aniridia. The managements were as follows: surgery (16.3%), chemotherapy and/or radiotherapy after surgery (61.6%), surgery after biopsy and chemotherapy (18.7%) and others (12.5%). The results of treatment included; complete or incomplete remission (72.5%), no response or aggravation (9.6%) and unknown (16.7%). The overall metastasis rate was 24.7%. The outcomes at the last follow up (ave. 33.2 mos.) were alive, dead and unknown due to follow up loss, in 72.1, 6.7 and 21.2%, respectively.
CONCLUSIONS
These demographic data and biological behaviors for renal tumors in Korea under the age of 20 years will lead to a better understanding of these rare tumors and to the optimal therapy for these young peoples.