Korean J Urol.  1987 Aug;28(4):495-500.

Studies on Blood Group Isoantigens in Uroepithelium -Determination of Isoantigens in Non-Malignant Epithelium of Tumor-Bearing Bladder-

• Kwon HY
• Yoon JB

Abstract

A and B blood type isoantigens were investigated in 17 cases surrounding bladder cancer by means of the specific red cell adherence test (SRCA). The tissue specimen were classified into positive, intermediate and negative groups according to SR CA reaction of the primary tumors. The histologically normal epithelium was SRCA-positive in 86.2 % of the specimens in the positive group and 70.0% in the negative, group; for hyperplastic epithelium it was 76.4 % and 50.0% and for the dysplastic epithelium it was 60.0% and 53.3 % respectively. The results may indicate that dedifferentiation expressed as the loss of blood group isoantigens has occurred in the histologically benign epithelium of the tumor-bearing bladders and that its occurrences is frequent in the bladder, associated with SRCA-negative tumors.

Keyword

blood group isoantigens; uroepithelium; bladder

MeSH Terms

Epithelium*
Isoantigens*
Urinary Bladder
Urinary Bladder Neoplasms
Isoantigens