Korean J Fertil Steril.  1999 Dec;26(3):355-362.

A Study on Clinical Response to Controlled Ovarian Hyperstimulation of In VitroFertilization and Embryo Transfer According to the Size of Baseline Ovarian Cyst

• Lee YS
• Jung BJ
• Lee SH
• Hur M

Abstract

OBJECTIVE
This study was performed to compare the clinical response to controlled ovarian hyperstimulation (COH) of in vitro fertilization and embryo transfer (IVF-ET) according to the size of baseline ovarian cyst. METHOD: From February 1992 to March 1999, a retrospective analysis was done of 272 cases who underwent COH using mid-luteal phase long protocol of gonadotropin-releasing hormone agonist (GnRH-a) for IVF-ET. These cases were divided into four group; group 1 (n=63) had cysts with mean diameters between 20.2 and 29.0 mm on their baseline ultrasound on cycle day 3, group 2 (n=57, 30.0~49.0mm), group 3 (n=68, >50.0mm) and control group (n=84). Cases were excluded according to the following criteria; pure male factor infertility, the presence of only one ovary, high CA-125 level and previous endometriosis.
RESULTS
There were no statistically significant differences between cases with baseline ovarian cyst <50.0 mm in diameter and control group in any of the parameters. However, cases with baseline ovarian cyst>50.0 mm in mean diameter needed more amount of human menopausal gonadotropin (hMG), showed significantly lower estradiol (E2) level, the number of follicle >15.0 mm on the day of human chorionic gonadotropin (hCG) administration, the number of oocytes retrieved, the number of mature oocytes, and pregnancy rate compared with control group.
CONCLUSION
This study suggests that cases with baseline overian cyst <50.0 mm in diameter do not adversely impact on IVF-ET outcome. However, cases with baseline ovarian cyst >50.0 mm in diameter had adverse effects on various parameters. Therefore, to improve the outcome of IVF-ET in these cases, ovarian cyst aspiration prior to initiating COH may be required.

MeSH Terms

Chorionic Gonadotropin
Embryo Transfer*
Embryonic Structures*
Endometriosis
Estradiol
Female
Fertilization in Vitro
Gonadotropin-Releasing Hormone
Gonadotropins
Humans
Infertility
Male
Oocytes
Ovarian Cysts*
Ovary
Pregnancy Rate
Retrospective Studies
Ultrasonography
Chorionic Gonadotropin
Estradiol
Gonadotropin-Releasing Hormone
Gonadotropins