Platelet Aggregability in the Patients with Peripheral Vestibulopathy

Kim, Young Doe; Cha, Chang Il; Cho, Joong Saeng; Lee, Kun Hee; Ahn, Hwoe Young

Abstract

BACKGROUND AND OBJECTIVES: Circulatory disturbance to vestibular organ has been regarded as one of the causes that bring about vertigo, and alteration of the platelet function is known to be an important factor inducing circulatory deficit. This study was designed to evaluate platelet aggregability in the patients with peripheral vestibulopathy, and to evaluate difference according to duration of illness.
MATERIALS AND METHODS
Platelet aggregation tests to adenosine diphosphate (ADP), ristocetin, epinephrine and collagen were performed in 10 normal subjects and 15 patients with peripheral vestibulopathy. Maximum aggregation rates from aggregation curves were compared between the two groups, and also between the two groups of patients who had different duration of illness.
RESULTS
In the patient group, platelet aggregations to ADP, ristocetin and collagen were increased compared to normal subjects and significant differences were found in aggregations to ADP and ristocetin. However, there was no significant difference according to different duration of illness in the patient group.
CONCLUSION
These results suggest that platelet aggregability is increased in the patients with peripheral vestibulopathy, and duration of illness does not affect platelet aggregability.