J Korean Radiol Soc.  2002 Feb;46(2):119-125. 10.3348/jkrs.2002.46.2.119.

Measurement of Perfusion of Pulmonary Nodules by Electron Beam Tomography

• Kim JA
• Choe KO
• Choi BW

• KMID: 1832974
• DOI: http://doi.org/10.3348/jkrs.2002.46.2.119

Abstract

PURPOSE
To investigate the perfusion of pulmonary nodules and the flow pattern revealed by electron beam tomography (EBT), and to evaluate their usefulness in the differential diagnosis of pulmonary nodules.
MATERIALS AND METHODS
A prospective perfusion study involving 28 nodules in 23 men and five women (mean age, 57 years) was performed using EBT with the multislice flow mode. There were four phases. Precontrast density (Hounsfield units, HU) in phase 0; perfusion, peak HU and time to peak in phase 1; and mean HU and percentage decrease of HU to peak HU of phase 1 in phases 2 and 3 were measured and compared according to the diagnosis.
RESULTS
Malignancy was diagnased in 19 cases [primary lung cancer (n=14); metastatic nodules (n=5)], while nine nodules were benign. Perfusion was significantly higher in malignant nodules than in benign (p<0.001) and a higher mean delay 1 HU (p<0.05) and a significantly short time to peak (p<0.05) were recorded in malignant nodules. In primary lung cancer cases, perfusion was significantly high compared with benign nodules (p<0.001), and a mean delay 1 HU was observed (p<0.05). There was no significant difference in perfusion between primary lung cancer and metastasis.
CONCLUSION
Perfusion and flow pattern data measured by EBT can provide the useful information for differentiation between malignant and benign pulmonary nodules.

Keyword

Lung neoplasms, CT; Computed tomography (CT), electron beam

MeSH Terms

Diagnosis
Diagnosis, Differential
Female
Humans
Lung Neoplasms
Male
Neoplasm Metastasis
Perfusion*
Prospective Studies
Tomography, X-Ray Computed*