Korean Circ J.  2013 Oct;43(10):645-654. 10.4070/kcj.2013.43.10.645.

A Bumpy and Winding but Right Path to Domestic Drug-Eluting Coronary Stents

  • 1Korea Cardiovascular Stent Research Institute of Chonnam National University, Gwangju, Korea. myungho@chollian.net


Restenosis and stent thrombosis remain major concerns after percutaneous coronary intervention for the treatment of coronary artery disease. The present review was undertaken in order to highlight the various coronary stents that have been investigated in our Heart Research Center, and how far we have come from the first heparin-coated stent first used in the late 1990s. Thereafter, from the abciximab-coated stent to the current gene-delivery stent and other newer agents, our group has applied a range of techniques in this field. However, in groups similar to ours, the restenosis rates of such stents are still high for second-generation drug-eluting stents (DESs). Moreover, our nation imports almost all of these types of stents from other countries. Thus, we need to develop domestic coronary stents. Research into newer DESs are warranted in Korea so as to achieve improved safety and efficacy outcomes.


Acute myocardial infarction; Coronary artery disease; Drug-eluting stents

MeSH Terms

Coronary Artery Disease
Myocardial Infarction
Percutaneous Coronary Intervention


  • Fig. 1 Emerging drug-eluting stents (DESs) under investigation at the Heart Center of Chonnam National University Hospital (CNUH). ACEI: angiotensin converting enzyme inhibitor, NO: nitric oxide, SiRNA: small interfering RNA.

  • Fig. 2 Comparison of the ISR area (mm2) between three types of stents, including the Akt-siRNA-embedded stent (adapted from Che et al. Biomaterials 2012;33:8548-56).84) ISR: in-stent restenosis, BMS: bare-metal stent, HA: hyaluronic acid.

Cited by  2 articles

Development of Novel Drug-Eluting Stents for Acute Myocardial Infarction
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Chonnam Med J. 2017;53(3):187-195.    doi: 10.4068/cmj.2017.53.3.187.

Preclinical Evaluation of a Novel Polymer-free Everolimus-eluting Stent in a Mid-term Porcine Coronary Restenosis Model
Kyung Hoon Cho, Myung Ho Jeong, Dae Sung Park, Moonki Kim, JungHa Kim, Jun-Kyu Park, Xiongyi Han, Dae Young Hyun, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
J Korean Med Sci. 2021;36(40):e259.    doi: 10.3346/jkms.2021.36.e259.


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