J Lab Med Qual Assur.
2003 Jun;25(1):207-209.
A Case of Acquired Hemophilia A
- Affiliations
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- 1Department of Laboratory Medicine, College of Medicine Kyung Hee University, Seoul, Korea. wileemd@khu.ac.kr
- 2Department of Internal Medicine, College of Medicine Kyung Hee University, Seoul, Korea.
Abstract
- Acquired hemophilia is a rare acquired bleeding disorder. It occurs most frequently in elderly patients and in patients with associated underlying diseases such as autoimmune disorders, rheumatoid arthritis, malignancies, and so on. It is caused by autoantibodies to factor VIII which deplete circulating factor VIII. We report a 78-year-old man with acquired hemophilia A who underwent subtotal gastrectomy for stomach cancer 7 years ago with no current evidence of recurrence. He has no bleeding tendency in the past nor family history for bleeding. On admission he had blood clots in both renal pelvis and sustaining hematuria. Laboratory tests revealed prolonged activated partial thromboplastin time(aPTT), decreased activity of factor VIII and evidence of factor VIII inhibitor.
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