Chonnam Med J.
2000 Jun;36(2):129-138.
Effects of Nitric Oxide on Voltage-dependent Potassium Currents in Vestibular Nuclear Neuron of the Rat
- Affiliations
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- 1Department of Physiology, Chonnam National University Medical School, Kwangju, Korea.
- 2Department of Pharmacology, Chonnam National University Medical School, Kwangju, Korea.
- 3Department of Emergency Medicine, Chonnam National University Medical School, Kwangju, Korea.
Abstract
- The effect of the nitrix oxide (NO) pathway on voltage-dependent potassium currents in rat vestibular nuclear neurons was investigated by using the whole cell patch clamp technique. When cells were held at -70 mV and depolarized from -60 mV to + 40 mV in 10 mV increments, sustained outward potassium currents were evoked. The outward potassium currents were decreased by the addition of 10 microM sodium nitroprusside (SNP). And 1 mM 8-bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP) produced a similar effects to those of 10 microM SNP. High EGTA containing pipette solution (11 mM) reduced the control currents and inhibited SNP induced outward potassium currents reduction. 1H-[1,2,4]oxadiazolo[4,3-a]quinozalin-1-one (ODQ), a specific inhibitor of soluble guanylyl cyclase, significantly blocked SNP induced reduction. These results suggest that nitric oxide blocks Ca2+-activated K+ channels in the medial vestibular nuclear neuron by activating guanylyl cyclase.
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