J Korean Med Sci.
2012 Jan;27(1):96-100. 10.3346/jkms.2012.27.1.96.
Early-onset Childhood Sarcoidosis with Incidental Multiple Enchondromatosis
- Affiliations
-
- 1Department of Pediatrics, Wonkwang University Sanbon Medical Center, Gunpo, Korea.
- 2Department of Pediatrics, Chungnam University Hospital, Daejeon, Korea.
- 3Department of Radiology, Hanyang University Medical Center, Seoul, Korea.
- 4Department of Nuclear Medicine, Hanyang University Medical Center, Seoul, Korea.
- 5Department of Pathology, Hanyang University Medical Center, Seoul, Korea.
- 6Department of Pediatrics, Hanyang University Medical Center, Seoul, Korea. cord@hanyang.ac.kr
- KMID: 1792987
- DOI: http://doi.org/10.3346/jkms.2012.27.1.96
Abstract
- The triad of rash, arthritis, and uveitis seems to be characteristic for early-onset childhood sarcoidosis. We describe an interesting case of early-onset childhood sarcoidosis coexisting enchondromatosis, which clinically masquerade as Langerhans cell histiocytosis. A 33 months old girl presented with skin rash, subcutaneous nodules with polyarthritis, and revealed the involvement of lymph nodes as well as spleen during work-up. She also presented with multiple osteolytic lesions which pathologically proven enchondromatosis. Oral prednisone was prescribed at 2 mg/kg/day for 2 months until when subcutaneous nodules and joint swellings almost disappeared, and then slowly tapered over a period of 5 months. We report an unusual case of early-onset childhood sarcoidosis presented with osteolytic bone lesions which were irrelevant to sarcoidosis.
Keyword
MeSH Terms
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Administration, Oral
Anti-Inflammatory Agents/therapeutic use
Arthritis/complications
Child, Preschool
Diagnosis, Differential
Enchondromatosis/*complications/*diagnosis/drug therapy/radiography
Exanthema/etiology
Female
Humans
Positron-Emission Tomography and Computed Tomography
Prednisone/therapeutic use
Sarcoidosis/*complications/*diagnosis/drug therapy/radiography
Whole Body Imaging
