J Korean Med Sci.  2010 Jul;25(7):1101-1104. 10.3346/jkms.2010.25.7.1101.

A Case of Lewis-Sumner Syndrome Showing Dramatic Improvement after Plasma Exchange

  • 1Department of Neurology, Pusan National University School of Medicine, Busan, Korea. dskim@pusan.ac.kr
  • 2Medical Research Institute, Pusan National University School of Medicine, Busan, Korea.


We report a patient with Lewis-Sumner syndrome (LSS) who showed an improvement only with plasma exchange (PE). The patient, 32-yr old man, had progressive multifocal motor-sensory deficits with persistent, multiple conduction blocks and marked slowing of NCVs. Nerve pathology supported a diagnosis of demyelinating neuropathy by revealing marked loss of myelinated fibers with inter- and intrafascicular variation. Although the patient was refractory to treatment with corticosteroid and intravenous immunoglobulin, PE produced a dramatic improvement. Our experience strongly proposes that PE should be tried for refractory LSS.


Lewis-Sumner Syndrome; Plasma Exchange; Conduction Block; Nerve Pathology; Cranial Nerve Diseases
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