J Korean Med Sci.  2008 Aug;23(4):727-730. 10.3346/jkms.2008.23.4.727.

Benign Schwannoma of the Liver: A Case Report

• Lee WH
• Kim TH
• You SS
• Choi SP
• Min HJ
• Kim HJ
• Lee OJ
• Ko GH

• KMID: 1785838
• DOI: http://doi.org/10.3346/jkms.2008.23.4.727

Abstract

A primary benign schwannoma of the liver is extremely rare. Only nine cases have been reported in the medical literature worldwide and no case has been reported in Korea previously. A 36-yr-old woman was admitted to our hospital with vague epigastric pain. The ultrasound and computed tomography scan revealed a multiseptated cystic mass in the right lobe of the liver. The mass was resected; it was found to be a 5x4x2 cm mass filled with reddish yellow fluid. The histological examination confirmed the diagnosis of a benign schwannoma, proven by positive immunoreaction with the neurogenic marker S-100 protein and a negative response to CD34, CD117 and smooth muscle actin. This is the first report of a benign schwannoma of the liver parenchyma in a Korean patient.

Keyword

Benign Schwannoma; Liver

MeSH Terms

Adult
Antigens, CD34/analysis
Female
Humans
Liver Neoplasms/diagnosis/*pathology
Neurilemmoma/diagnosis/*pathology
Proto-Oncogene Proteins c-kit/analysis

Figure

• 

  Fig. 1 Ultrasound findings of the mass. A 4.5-cm sized round hypoechoic mass with multiple central echogenic bands in the right lobe of the liver (segment V).

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  Fig. 2 Abdominal computed tomography shows a 5 cm smooth margined low-attenuating mass in the right lobe of liver (segment V), containing multiple central septations.

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  Fig. 3 A photograph showing the cut section of the tumor: The specimen was 5 × 4 × 2 cm. A multi-septated cyst that was previously opened, measuring 4 × 4 cm. The cyst was 1 cm from the resection margin. The cyst contained 10 soft tissues. The wall thickness measured 0.4 cm.

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  Fig. 4 (A) Spindle cell tumor with a mixture of two growth patterns, Antoni A and Antoni B, is seen. In the Antoni A pattern of growth, elongated cells were arranged in areas of moderate to high cellularity (black arrow). In the Antoni B pattern of growth, the tumor was less densely cellular, had a loose meshwork of cells, as well as microcysts and myxoids changes (red arrow) (H&E, ×100). (B) Spindle cell tumor with cells arranged in whorls in a storiform pattern is seen (H&E, ×200).

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  Fig. 5 A photograph of immunochemical staining with S-100 protein: The tumor is composed of bundles of compact spindle cells that are immunoreactive to the S-100 protein (×200).

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