Yonsei Med J.  2009 Feb;50(1):169-173. 10.3349/ymj.2009.50.1.169.

Ovarian Thecoma with Virilizing Manifestations

• Lee MH
• Moon YJ
• Ha CW
• Hoh JK

• KMID: 1782986
• DOI: http://doi.org/10.3349/ymj.2009.50.1.169

Abstract

A 29-year-old woman presented with secondary amenorrhea, primary infertility, and virilization, which had developed over the past 2 years was suspected to have a virilizing tumor at her left ovary. Her serum testosterone level was markedly elevated (380 ng/dL). Left salpingooophorectomy was performed, and histopathological examination revealed a thecoma of the left ovary. The postoperative serum testosterone level returned to 65 ng/dL. The patient did not have regression of virilism soon. However, the patient had a normal menstruation 29 days after surgery and gave birth to a baby 13 months after surgery.

Keyword

Virilism; thecoma; testosterone

MeSH Terms

Adult
Female
Humans
Menstruation
Ovarian Neoplasms/blood/*complications/*surgery
Ovariectomy
Pregnancy
Pregnancy Outcome
Testosterone/blood
Thecoma/blood/*complications/*surgery
Virilism/blood/*etiology/surgery

Figure

• 

  Fig. 1 Transvaginal ultrasonography of a homogenousechoic mass originated in the left ovary (A), and abdominal and pelvic computed tomography (CT) scans of a left ovarian solid mass which was well-demarcated, round, homogenous and well-enhanced. No pathologic findings of other pelvic organs, ascites, and lymphatic enlargements were detected (B).

• 

  Fig. 2 A smooth-surfaced, yellowish, solid, and movable tumor was found to originate in the left ovary, measured 7 × 5 cm.

• 

  Fig. 3 A thecoma consisting of spindle cells with blunt ended nuclei and ill defined cytoplasm. The solid mass was consisted of fascicles of stromal cells, and some were vacuolated (H & E, (A) × 100, (B) × 400).

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  Fig. 4 Masson trichrome staining shows very little collagen deposition in focal stromal pattern (arrow) ((A) × 100, (B) × 400).

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