J Korean Med Sci.  2007 Jun;22(3):387-392. 10.3346/jkms.2007.22.3.387.

Intima-media Thickness and Arterial Stiffness of Carotid Artery in Korean Patients with Behcet's Disease

• Rhee MY
• Chang HK
• Kim SK

• KMID: 1778342
• DOI: http://doi.org/10.3346/jkms.2007.22.3.387

Abstract

Behcet's disease (BD) is a systemic vasculitis involving diverse sizes of arteries and veins. We performed this study to evaluate the vascular changes by assessment of the arterial stiffness and intima-media thickness (IMT) of carotid artery in Korean patients with BD. Forty-one patients with BD and age-, and sex-matched 53 healthy subjects were recruited in this study. Carotid arterial stiffness and IMT were assessed by using high-resolution B-mode ultrasonography. Arterial stiffness parameters such as carotid arterial distensibility coefficient, stiffness index, and incremental elastic modulus (E(inc)) were significantly increased in BD patients compared with those in healthy subjects, but not in IMT. Positive relationship was noted between age and IMT, whereas age of onset was significantly associated with arterial stiffness in BD. This finding suggests impaired endothelial function before visible structural changes of arterial wall in BD. Age and age of onset may be an independent risk factor for carotid IMT and arterial stiffness, respectively. Further studies in more large populations are required to confirm our results.

Keyword

Arterial Stiffness; Intima-media Thickness; Carotid Artery; Behcet's Disease

MeSH Terms

Adolescent
Adult
Age Factors
Arteries/pathology
Behcet Syndrome/*diagnosis/*pathology
Carotid Arteries/*pathology
Carotid Artery Diseases/pathology
Case-Control Studies
Female
Humans
Korea
Male
Middle Aged
Tunica Intima/pathology
Tunica Media/pathology

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