Yonsei Med J.  2006 Dec;47(6):870-872. 10.3349/ymj.2006.47.6.870.

Clear Cell Basal Cell Carcinoma with Sialomucin Deposition

• Kim DY
• Cho SB
• Chung KY
• Kim YC

• KMID: 1777178
• DOI: http://doi.org/10.3349/ymj.2006.47.6.870

Abstract

Clear cell basal cell carcinoma (BCC) is a variant of BCC with a characteristic clear cell component that may occupy all or part of the tumor islands. Periodic acid-Schiff (PAS) staining for glycogen is variably positive, and mild deposition of sulfated mucin has been noted. However, to our knowledge, clear cell BCC with sialomucin deposition has not been reported. Here we report a case of clear cell BCC showing sialomucin deposition. The clear tumor cells stained with PAS and showed incomplete diastase-resistance. In addition, mucin staining with alcian blue was positive at pH 2.5 but not at pH 0.5.

Keyword

Basal cell carcinoma; sialomucins

MeSH Terms

Sialomucins/*analysis
Humans
Female
Carcinoma, Basal Cell/classification/diagnosis/*pathology
Aged, 80 and over

Figure

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  Fig. 1 A solitary coin sized, irregularly pigmented, and depressed erosion with marginal elevation in the right infraorbital area.

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  Fig. 2 Irregularly arranged basaloid cells and clear vacuolated cells with peripheral palisading of basaloid cells within infiltrating tumor lobules (hematoxylin and eosin, A, × 40; B, × 400). C. Tumor cells sparsely stained with PAS, and incomplete diastase-resistance (d-PAS, × 200). D. Tumor cells were stained with alcian blue at pH 2.5 (Alcian blue, × 200).

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