J Korean Med Sci.  2004 Oct;19(5):688-692. 10.3346/jkms.2004.19.5.688.

Maternal Serum Levels of VCAM-1, ICAM-1 and E-selectin in Preeclampsia

• Kim SY
• Ryu HM
• Yang JH
• Kim MY
• Ahn HK
• Lim HJ
• Shin JS
• Woo HJ
• Park SY
• Kim YM
• Kim JW
• Cho EH

• KMID: 1733510
• DOI: http://doi.org/10.3346/jkms.2004.19.5.688

Abstract

Endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. The aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) in sera of normal and preeclamptic pregnancies. We studied the serum levels of sVCAM-1, sICAM-1 and sE-selectin in normal pregnant women (n=63), mild preeclampsia (n=33) and severe preeclampsia (n=82). Concentrations of soluble adhesion molecules were determined with enzyme-linked immunoassay (ELISA). Serum concentrations of sVCAM-1 were significantly higher in both mild (p=0.004) and severe preeclampsia (p=0.000) than normal pregnancy. There were also significant differences in sVCAM-1 levels between mild and severe preeclampsia (p=0.002). sICAM-1 levels of severe preeclampsia were statistically different from those of normal pregnancy (p=0.038). Levels of sE-selectin were elevated in both mild (p=0.011) and severe preeclampsia (p=0.000) compared to normal pregnancy, but no statistical difference between the mild and severe preeclampsia (p=0.345). These results suggest that all three soluble adhesion molecules are increased in severe preeclampsia, and sVCAM-1 among them may be useful in predicting the severity of preeclampsia.

Keyword

Pre-Eclampsia; Cell Adhesion Molecules; Vasurlar Cell Adhesion Molecule-1, Intercellular Adhesion Molecule-1, E-Selectin

MeSH Terms

Adult
Biological Markers
Cell Adhesion Molecules/*blood
E-Selectin/blood
Female
Humans
Intercellular Adhesion Molecule-1/blood
Pre-Eclampsia/*blood
Pregnancy
Severity of Illness Index
Solubility
Vascular Cell Adhesion Molecule-1/blood

Figure

• 

  Fig. 1 Concentrations of soluble VCAM-1 (A), ICAM-1 (B), and E-selectin (C) in normal pregnancy (NP), mild preeclampsia (MPE) and severe preeclampsia (SPE). *p<0.05, comparison with normal pregnancy; †p<0.05, comparison with both normal pregnancy and mild preeclampsia.

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