Korean J Pathol.  1998 Sep;32(9):694-696.

Primary Malignant Melanoma of the Esophagus: A case report

• Maeng LS
• Kim KM
• Lee EJ
• Lee A
• Shim SI

Abstract

This report presents an unusual case of primary malignant melanoma in the midesophagus. The patient was a 36-year-old woman presenting with dysphagia and odynophagia. The resected esophagus and proximal stomach showed a dark purple large polypoid mass, measuring 6.0 3.3 2.0 cm, with a diffuse tan pigmentation of surrounding mucosa in the mid-esophagus and two small daughter nodules, up to 1.2 0.3 cm, in the lower esophagus near the gastro-esophageal junction. A microscopic examination revealed a malignant melanoma of epithelioid cell type confined to mucosa and submucosa with a diffuse melanosis. Cytoplasmic immunoreactivity for HMB 45 and S-100 protein were noted. An electron microscopic examination revealed large, loosely cohesive variable shaped cells with a few cytoplasmic premelanosomes.

Keyword

Melanoma; Esophagus; Melanosis

MeSH Terms

Adult
Cytoplasm
Deglutition Disorders
Epithelioid Cells
Esophagus*
Female
Humans
Melanoma*
Melanosis
Mucous Membrane
Nuclear Family
Pigmentation
S100 Proteins
Stomach
Triacetoneamine-N-Oxyl
S100 Proteins
Triacetoneamine-N-Oxyl