Korean J Pathol.  1989 Mar;23(1):75-84.

Immunohistochemical Demonstration of Neuron-Specific Enolase and Chromogranin and Ultrastructural Studies on Endocrine Carcinoma of the Uterine Cervix

• Chun HJ
• Kee KH
• Lim SC
• Song HS
• Kim MW
• Han SJ
• Suh CH

Abstract

Three cases of endocrine carcinoma, well differentiated type of the uterine cervix, were found in a study of 201 cases listed in the files of the Chosun University medical college as malignant tumors in the uterine cervix based on light microscopic pattern, three cases were divided into pure endocrine carcinoma (2 cases) and endocrine carcinoma mixed with large cell nonkeratinizing squamous cell carcinoma (1 case). The histologic picture of these lesions varied from solid sheets to glandular patterns and show monotonous and intermediate size of neclei. Argyrophilic granules were demonstrated in two pure forms by Grimelius stain, and Masson-Hamperl (argentaffin) stain were negative in all three cases. Immunohistochemical studies demonstrated positive reactions for neuron specific enolase and chromogranin in all three cases. Although endocrine symptoms were not found, ACTH were demonstrated in two pure forms. Ultrastructural studies disclose distinct membrane bounded neurosecretory granules and well defined Golgi complex.

Keyword

Endocrine carcinoma; Uterine cervix