Korean J Gastroenterol.  2011 Aug;58(2):117-120. 10.4166/kjg.2011.58.2.117.

Localized Gastric Amyloidosis

• Lee YN
• Hong SJ
• Kim HK

• KMID: 1718421
• DOI: http://doi.org/10.4166/kjg.2011.58.2.117

Abstract

No abstract available.

MeSH Terms

Amyloidosis/*diagnosis/pathology/ultrasonography
Endoscopy, Gastrointestinal
Female
Humans
Middle Aged
Stomach Diseases/*diagnosis/pathology/ultrasonography
Tomography, X-Ray Computed

Figure

• 

  Fig. 1. Endoscopic findings. (A) It showed prominent and thickened rugal folds with hard consistency in the greater curvature of the mid-body. Yellowish background color was observed through the thinned atrophic mucosa on the lesion. (B) Small erosions were noted on the lesion.

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  Fig. 2. EUS finding. It showed multiple hyperechoic foci with posterior acoustic shadow in the diffuse hypoechoic thickening of the mucosa and submucosa.

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  Fig. 3. Pathologic findings. (A, B) Large acellular eosinophilic masses were present in the lamina propria (H&E, ×40, ×100). (C) Congo red stain revealed pink-red deposits of amyloid (×100). (D) Polarizing micsorscopy showed the yellow-green birefringence of the deposits (×200).

Reference

References

1. Husby G. A chemical classification of amyloid. Correlation with different clinical types of amyloidosis. Scand J Rheumatol. 1980; 9:60–64.

2. Tan SY, Pepys MB. Amyloidosis. Histopathology. 1994; 25:403–414.

3. Gertz MA, Comenzo R, Falk RH, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th Internatio-nal Symposium on Amyloid and Amyloidosis, Tours, France, 18–22 April 2004. Am J Hematol. 2005; 79:319–328.

4. Zheng W, Song S, Zhu Q, Tan H, Li P, Jiang Y. Local amyloidosis of stomach. Zhonghua Wai Ke Za Zhi. 1998; 36:415–416.

5. Björnsson S, Jóhannsson JH, Sigurjónsson F. Localized primary amyloidosis of the stomach presenting with gastric hemorrhage. Acta Med Scand. 1987; 221:115–119.

6. Tada S, Iida M, Iwashita A, et al. Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis. Gastrointest Endosc. 1990; 36:10–14.

7. Yamada M, Hatakeyama S, Tsukagoshi H. Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and AA (secondary) amyloidosis: diagnostic value of gastric biopsy. Hum Pathol. 1985; 16:1206–1211.

8. Röcken C, Sletten K. Amyloid in surgical pathology. Virchows Arch. 2003; 443:3–16.

9. Jaskowski TD, Litwin CM, Hill HR. Detection of kappa and lambda light chain monoclonal proteins in human serum: automated im-munoassay versus immunofixation electrophoresis. Clin Vaccine Immunol. 2006; 13:277–280.

10. Sattianayagam PT, Hawkins PN, Gillmore JD. Systemic amyloidosis and the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2009; 6:608–617.

11. Hamidi Asl K, Liepnieks JJ, Nakamura M, Benson MD. Organ-specific (localized) synthesis of Ig light chain amyloid. J Immunol. 1999; 162:5556–5560.

12. Reddy AB, Wright RA, Wheeler GE, Nazer H. Nonobstructive gas-troparesis in amyloidosis improved with metoclopramide. Arch Intern Med. 1983; 143:247–248.

13. Tada S, Iida M, Yao T, Kitamoto T, Yao T, Fujishima M. Intestinal pseudoobstruction in patients with amyloidosis: clinicopathologic differences between chemical types of amyloid protein. Gut. 1993; 34:1412–1417.

14. Usui M, Matsuda S, Suzuki H, Hirata K, Ogura Y, Shiraishi T. Gastric amyloidosis with massive bleeding requiring emergency surgery. J Gastroenterol. 2000; 35:924–928.