J Korean Med Sci.  2010 Dec;25(Suppl):S41-S45. 10.3346/jkms.2010.25.S.S41.

Occupational Reproductive Function Abnormalities and Bladder Cancer in Korea

• Park J
• Shin KS
• Kim Y

• KMID: 1714066
• DOI: http://doi.org/10.3346/jkms.2010.25.S.S41

Abstract

The purpose of this study was to review occupational reproductive abnormalities and occupational bladder cancer in Korea and to discuss their toxicological implications. Reproductive dysfunction as a result of 2-bromopropane poisoning was first reported in Korean workers. In 1995, 23 of the 33 workers (25 female and 8 male workers) who were exposed to 2-bromopropane during the assembly of tactile switch parts developed reproductive and/or hematopoietic disorders. A total of 17 (68%) workers were diagnosed with ovarian failure. Two of the eight male workers experienced azoospermia and four workers experienced some degree of oligospermia or reduced sperm motility. In summary, 2-bromopropane poisoning caused severe reproductive effects in Korean workers. The prognosis was poor for reproductive dysfunction. A few cases of occupational bladder cancer have been reported in Korea, whereas other cancers of the urinary tract have not been reported after occupational exposure. A few cases of benzidine-induced cancer have been reported in Korea and 592 workers in Japan have received compensation for benzidine and beta-naphthylamine-induced cancer. In conclusion, a few cases of benzidine-induced occupational bladder cancer have been reported in Korea. However, benzidine-induced bladder cancer will likely be an important occupational health issue in Korea in the coming years.

Keyword

Occupational Diseases; Reproduction; Urinary Bladder Neoplasms

MeSH Terms

2-Naphthylamine/toxicity
Azoospermia/chemically induced/epidemiology
Benzidines/toxicity
Female
Humans
Hydrocarbons, Brominated/toxicity
Infertility/*chemically induced/*epidemiology
Male
Occupational Diseases/*chemically induced/*epidemiology
Occupational Exposure/adverse effects
Oligospermia/chemically induced/epidemiology
Primary Ovarian Insufficiency/chemically induced/epidemiology
Republic of Korea
Sperm Motility/drug effects
Urinary Bladder Neoplasms/*chemically induced/*epidemiology

Reference

1. US EPA. Toxic Substances Control Act (TSCA). Chemical substance inventory-revised inventory synonym and preferred name file. 2000. Washington, DC: Office of Pollution, Prevention, and Toxics.

2. Park J, Hisanaga N, Kim Y. Transfer of occupational health problems from a developed to a developing country: Lessons from the Japan-South Korea Experience. Am J Ind Med. 2009. 52:625–632.

3. Schrader SM, Kanitz MH. Gold E, Schenker M, Lasley B, editors. Occupational hazards to male reproduction. Occupational medicine. State of the art reviews: reproductive hazards. 1994. vol. 9. Philadelphia: Hanley & Bilfus;405–414.

4. Baranski B. Effects of the workplace on fertility and related reproductive outcomes. Environ Health Perspect. 1993. 101:Suppl 2. 81–90.

5. Park JS, Kim Y, Park DW, Choi KS, Park SH, Moon YH. An outbreak of hematopoietic and reproductive disorders due to solvents containing 2-bromopropane in an electronic factory, South Korea: Epidemiological survey. J Occup Health. 1997. 39:138–143.

6. Kim Y, Jung K, Hwang T, Jung G, Kim H, Park J, Kim J, Park J, Park D, Park S, Choi K, Moon Y. Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane. Scand J Work Environ Health. 1996. 22:387–391.

7. Låg M, Søderlund EJ, Omichinski JG, Brunborg G, Holme JA, Dahl JE, Nelson SD, Dybing E. Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes. Chem Res Toxicol. 1991. 4:528–534.

8. Låg M, Omichinski JG, Dybing E, Nelson SD, Søderlund EJ. Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning. Chem Biol Interact. 1994. 93:73–84.

9. Koh JM, Kim CH, Hong SK, Lee KU, Kim YT, Kim OJ, Kim GS. Primary ovarian failure caused by a solvent containing 2-bromopropane. Eur J Endocrinol. 1998. 138:554–556.

10. Hong B, Hong JH, Park SW, Kim HG, Ahn TY. Long-term follow-up of abnormal spermatogenesis after exposure to solvent containing 2-bromopropane. Korean J Androl. 2002. 20:131–136.

11. Ichihara G, Asaeda N, Kumazawa T, Tagawa Y, Kamijima M, Yu X, Kondo H, Nakajima T, Kitoh J, Yu IJ, Moon Y, Hisanaga N, Takeuchi Y. Testicular toxicity of 2-bromopropane. J Occup Health. 1996. 38:205–206.

12. Ichihara G, Asaeda N, Kumazawa T, Tagawa Y, Kamijima M, Yu X, Kondo H, Nakajima T, Kitoh J, Yu IJ, Moon Y, Hisanaga N, Takeuchi Y. Testicular and hematopoietic toxicity of 2-bromopropane, a substitute for ozone layer-depleting chlorofluorocarbons. J Occup Health. 1997. 39:57–63.

13. Kamijima M, Ichihara G, Kitoh J, Tsukamura H, Maeda KI, Yu X, Xie Z, Nakajima T, Asaeda N, Hisanaga N, Takeuchi Y. Ovarian toxicity of 2-bromopropane in the non-pregnant female rat. J Occup Health. 1997. 39:144–149.

14. Lim CH, Maeng SH, Lee JY, Chung YH, Kim TG, Park JH, Moon YH, Yu IJ. Effects of 2-bromopropane on the female reproductive function in Sprague-Dawley rats. Ind Health. 1997. 35:278–284.

15. Yu IJ, Chung YH, Lim CH, Maeng SH, Lee JY, Kim HY, Lee SJ, Kim CH, Kim TG, Park JS, Moon YH. Reproductive toxicity of 2-bromopropane in Sprague Dawley rats. Scand J Work Environ Health. 1997. 23:281–288.

16. Yu X, Kamijima M, Ichihara G, Li W, Kitoh J, Xie Z, Shibata E, Hisanaga N, Takeuchi Y. 2-Bromopropane causes ovarian dysfunction by damaging primordial follicles and their oocytes in female rats. Toxicol Appl Pharmacol. 1999. 159:185–193.

17. Son HY, Kim YB, Kang BH, Cho SW, Ha CS, Roh JK. Effects of 2-bromopropane on spermatogenesis in the Sprague-Dawley rat. Reprod Toxicol. 1999. 13:179–187.

18. Wu X, Faqi AS, Yang J, Ding X, Jiang X, Chahoud I. Male reproductive toxicity and beta-luteinizing hormone gene expression in sexually mature and immature rats exposed to 2-bromopropane. Hum Exp Toxicol. 1999. 18:683–690.

19. Sekiguchi S, Suda M, Zhai YL, Honma T. Effects of 1-bromopropane, 2-bromopropane, and 1,2-dichloropropane on the estrous cycle and ovulation in F344 rats. Toxicol Lett. 2002. 126:41–49.

20. Yun JS, Kim KH, Kim DK, Cho BM, Choi OH. The effect of 2-bromopropane, organic solvent on ovarian function of reproductive women: 7-years follow-up. Korean J Obstet Gynecol. 2002. 45:1578–1587.

21. Kim Y, Park J, Moon Y. Hematopoietic and reproductive toxicity of 2-bromopropane, a recently introduced substitute for chlorofluorocarbons. Toxicol Lett. 1999. 108:309–313.

22. Ichihara G, Ding X, Yu X, Wu X, Kamijima M, Peng S, Jiang X, Takeuchi Y. Occupational health survey on workers exposed to 2-bromopropane at low concentrations. Am J Ind Med. 1999. 35:523–531.

23. Yu MC, Skipper PL, Tannenbaum SR, Chan KK, Ross RK. Arylamine exposures and bladder cancer risk. Mutat Res. 2002. 506-507:21–28.

24. Olfert SM, Felknor SA, Delclos GL. An updated review of the literature: risk factors for bladder cancer with focus on occupational exposures. South Med J. 2006. 99:1256–1263.

25. Kim Y, Park J, Shin YC. Dye-manufacturing workers and bladder cancer in South Korea. Arch Toxicol. 2007. 81:381–384.

26. Kim SA, Lee JW, Kim BW, Shin YC. Bladder cancer with exposure to benzidine-based dyes of dyer. Korean J Occup Environ Med. 1999. 11:304–312.

27. Tsuchiya K, Okubo T, Ishizu S. An epidemiological study of occupational bladder tumors in the dye industry of Japan. Br J Ind Med. 1975. 32:203–209.

28. You XY, Chen JG, Hu YN. Studies on the relation between bladder cancer and benzidine or its derived dyes in Shanghai. Br J Ind Med. 1990. 47:544–552.

29. Nishimura I. On aniline tumors of the bladder (case report). Jpn J Urol. 1940. 29:733–749.

30. Ishizu S. Management of occupational bladder cancers by urinary cytology. 1975. Japan Dyestuff & Industrial Chemicals Association.

31. Miura T. Handbook of Occupational Health. 1996. 2nd ed. Kawasaki: Institute for Science of Labour;1705–1755.

32. Japan Occupational Safety and Health Resource Center (JOSHRC). JOSHRC Newsletter. 2005. 08. 19.