Dement Neurocogn Disord.  2014 Jun;13(2):46-49. 10.12779/dnd.2014.13.2.46.

Vertebral Artery Dissection Presenting as Transient Global Amnesia: A Case Report and Review of Literature

Affiliations
  • 1Department of Neurology, Konkuk University Medical Center, Seoul, Korea. alzdoc@kuh.ac.kr
  • 2Center for Geriatric Neuroscience Research, Institute of Biomedical Science, Konkuk University, Seoul, Korea.

Abstract

Vertebral artery dissection is one of the most common causes of stroke in young adults. The course of the vertebral artery dissection is usually benign, and pure transient amnesia as an initial symptom has been rarely reported. We describe a patient with vertebral artery dissection who presented with acute transient amnesia, and review the medical literatures about the pathophysiological mechanism of transient global amenesia (TGA). This case could be a one of evidence which supports the cerebrovascular mechanism of TGA.

Keyword

Transient global amnesia; Vertebral artery dissection; Cerebrovascular

MeSH Terms

Amnesia
Amnesia, Transient Global*
Humans
Stroke
Vertebral Artery Dissection*
Young Adult

Figure

  • Fig. 1 Brain diffusion weighted (A) and FLIR images (B, C) at admission revealed no high signal.

  • Fig. 2 An unruptured, fusiform dissecting aneurysm at the right vertebral artery was suspected on magnetic resonance angiography (A) and confirmed on conventional angiography (B).


Reference

1. Lee VH, Brown RD Jr, Mandrekar JN, Mokri B. Incidence and outcome of cervical artery dissection: A population-based study. Neurology. 2006; 67:1809–1812.
Article
2. Debette S, Leys D. Cervical-artery dissections: Predisposing factors, diagnosis, and outcome. Lancet Neurol. 2009; 8:668–678.
Article
3. Sedlaczek O, Hirsch JG, Grips E, Peters CN, Gass A, Wohrle J, et al. Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology. 2004; 62:2165–2170.
Article
4. Lampl Y, Sadeh M, Lorberboym M. Transient global amnesia-not always a benign process. Acta Neurol Scand. 2004; 110:75–79.
Article
5. Guillery-Girard B, Quinette P, Desgranges B, Piolino P, Viader F, de la Sayette V, et al. Long-term memory following transient global amnesia: An investigation of episodic and semantic memory. Acta Neurol Scand. 2006; 114:329–333.
Article
6. Le Pira F, Giuffrida S, Maci T, Reggio E, Zappala G, Perciavalle V. Cognitive findings after transient global amnesia: Role of prefrontal cortex. Appl Neuropsychol. 2005; 12:212–217.
Article
7. Jager T, Bazner H, Kliegel M, Szabo K, Hennerici MG. The transience and nature of cognitive impairments in transient global amnesia: A meta-analysis. J Clin Exp Neuropsychol. 2009; 31:8–19.
Article
8. Bartsch T, Deuschl G. Transient global amnesia: Functional anatomy and clinical implications. Lancet Neurol. 2010; 9:205–214.
Article
9. Kim J, Kwon Y, Yang Y, Jang IM, Chang Y, Park YH, et al. Clinical experience of modified diffusion-weighted imaging protocol for lesion detection in transient global amnesia: An 8-year large-scale clinical study. J Neuroimaging. 2013.
Article
10. Bartsch T, Alfke K, Stingele R, Rohr A, Freitag-Wolf S, Jansen O, et al. Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae. Brain. 2006; 129:2874–2884.
Article
11. Pearce JM, Bogousslavsky J. 'Les ictus amnesiques' and transient global amnesia. Eur Neurol. 2009; 62:188–192.
12. Bartsch T, Alfke K, Deuschl G, Jansen O. Evolution of hippocampal CA-1 diffusion lesions in transient global amnesia. Ann Neurol. 2007; 62:475–480.
Article
13. Milusheva EA, Baranyi M. Implication of ionotropic glutamate receptors in the release of noradrenaline in hippocampal CA1 and CA3 subregions under oxygen and glucose deprivation. Neurochem Int. 2003; 43:543–550.
Article
14. Jang JW, Park SY, Hong JH, Park YH, Kim JE, Kim S. Different risk factor profiles between transient global amnesia and transient ischemic attack: A large case-control study. Eur Neurol. 2014; 71:19–24.
Article
15. Hodges JR, Warlow CP. Syndromes of transient amnesia: Towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry. 1990; 53:834–843.
Article
16. Pantoni L, Bertini E, Lamassa M, Pracucci G, Inzitari D. Clinical features, risk factors, and prognosis in transient global amnesia: A follow-up study. Eur J Neurol. 2005; 12:350–356.
Article
17. Chung CP, Hsu HY, Chao AC, Chang FC, Sheng WY, Hu HH. Detection of intracranial venous reflux in patients of transient global amnesia. Neurology. 2006; 66:1873–1877.
Article
18. Akkawi NM, Agosti C, Borroni B, Padovani A. Detection of intracranial venous reflux in patients of transient global amnesia. Neurology. 2007; 68:163. author reply 163.
Article
19. Schreiber SJ, Doepp F, Klingebiel R, Valdueza JM. Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia. J Neurol Neurosurg Psychiatry. 2005; 76:509–513.
Article
20. Georgiadis D, Lanczik O, Schwab S, Engelter S, Sztajzel R, Arnold M, et al. IV thrombolysis in patients with acute stroke due to spontaneous carotid dissection. Neurology. 2005; 64:1612–1614.
Article
Full Text Links
  • DND
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr