J Korean Soc Magn Reson Med.  2014 Mar;18(1):59-63. 10.13104/jksmrm.2014.18.1.59.

SAPHO Syndrome in a Patient with Breast Cancer Mimicking Bone Metastasis: A Case Report

• Ko K
• Suh HJ
• You JY
• Jung SY
• Kwon Y
• Koh YW

• KMID: 1683781
• DOI: http://doi.org/10.13104/jksmrm.2014.18.1.59

Abstract

A 66-year-old woman was transferred to our hospital due to her right breast cancer. Preoperative breast MRI shows 1.9 cm malignancy on her right breast (cT1N0M0) and incidentally found osteosclerotic change of left coststernoclavicular region. Bone scintigraphy showed hot uptake and the possibility of bone metastasis was not excluded. However, because the bone metastasis is not common in early stage cancer and the costosternoclavicular region is not common site, other possibility should be considered. SAPHO syndrome can be diagnosed even in the absence of dermatosis when there is an axial or appendicular osteitis and hyperostosis, especially in costosternoclavicular region. Though breast imaging specialists are not accustomed to this disease entity, awareness and diagnosis of the SAPHO syndrome can help differentiate bone metastasis.

Keyword

Breast cancer; SAPHO syndrome; Costosternoclavicular region

MeSH Terms

Acquired Hyperostosis Syndrome*
Aged
Breast Neoplasms*
Breast*
Diagnosis
Female
Humans
Hyperostosis
Magnetic Resonance Imaging
Neoplasm Metastasis*
Osteitis
Radionuclide Imaging
Skin Diseases
Specialization