Korean J Dermatol.  1980 Dec;18(6):529-537.

Daily Topical Sequential Triple Therapy of Tretinoin, Betamethasone Valerate and Hydroquinone on Melasma

• Kim HK
• Kim SK
• Hwang SW

Abstract

Daily topical sequential triple therapy(tretinoin, betamethasone valerate and hydroquinone), as proposed by Kligman et al and Gano et al, has been performed on 29 Korean female patients with melasma. After 4 weeks treatment with 2% hydroquinone cream, only three of eight patients (37. 5%) showed good to excellent results. However, after 4 weeks treatment with 4% hydroquinone cream, twelve of twentyone patients (57. 1%) showed good to excellent results and its therapeutic effects appeared more rapidly than the former group. Overall, after 4 weeks treatment. 96.6% of the total group showed fair to excellent results of which 57. 7% had a good to excellent rating. The fair-com- plexioned Koreans had a better response than dark-complexioned.

MeSH Terms

Betamethasone Valerate*
Betamethasone*
Female
Humans
Melanosis*
Tretinoin*
Betamethasone
Betamethasone Valerate
Tretinoin